I think you've found the right two casters to play for an all Shadows pairing. Issyria Shadows is generally one of the best options Ret has right now, and I think Vyros1 provides a pretty good compliment in the armor cracking department, which is really Issyria's only problem. That said, I think there's room for refinement with the above.
For Issyria, I'm not in love with the Hyperion as much as I used to be. The changes to terrain in SR2017 combined with Ancillary going to RNG 3 instead of 5 have been way more impactful than I first thought. Also, a Hype with no Arcanist feels a little underwhelming all told. Finally, Blinding Light is the strongest part of Issyria's kit right now, so I'd want at least one arc node to make sure I can get mileage out of that. Nemo3 with Storm Striders are huge problems into basically all of Ret, so I definitely want the ability to BL those guys. To that end, I've been playing the following to great success:
conflictchamber.com/#c5201b_-0AdUhI0u3y3y4V3X3X3-c_3m3o3m3ohPRetribution Army - 75 / 75 points
[Theme] Shadows of the Retribution
(Issyria 1) Issyria, Sibyl of Dawn [+29]
- Hemera [16]
- Phoenix [18]
Arcanist Mechanik [2]
Arcanist Mechanik [2]
Eiryss, Angel of Retribution [0(6)]
Mage Hunter Assassin [0(4)]
Mage Hunter Assassin [4]
Narn, Mage Hunter of Ios [0(6)]
Mage Hunter Infiltrators (max) [13]
Mage Hunter Strike Force (max) [16]
- Mage Hunter Strike Force Commander [4]
Mage Hunter Strike Force (max) [16]
- Mage Hunter Strike Force Commander [4]
Spears of Scyrah [9]
Issyria almost never uses AA, but I haven't found that I miss it too terribly much.
For Vyros1, I would consider some of the new Vyre lights instead of Griffons. You lose a little bit of threat distance, but hit harder and get really nice guns on the approach. This is my current (untested) version of Vyros1 I'm looking at:
conflictchamber.com/#c5201b_-0A0D1g2wjsjsd_jtjt3y3y3y3-c-3uhPdK3uRetribution Army - 75 / 75 points
[Theme] Shadows of the Retribution
(Vyros 1) Dawnlord Vyros [+28]
- Chimera [8]
- Griffon [8]
- Harpy [9]
- Harpy [9]
- Imperatus [22]
- Siren [8]
- Siren [8]
Arcanist Mechanik [2]
Arcanist Mechanik [2]
Arcanist Mechanik [2]
Narn, Mage Hunter of Ios [0(6)]
Mage Hunter Infiltrators (min) [8]
- Soulless Escort (1) [1]
Spears of Scyrah [9]
- Eiryss, Mage Hunter Commander [6]
- Soulless Escort (1) [1]
Very similar ideas to yours, just dropping the MHI to min (since I only really care about them as feat targets) and changing up the jack package. The Chimera could very easily become a second Griffon, just depends how much you value Stranglehold. Also, Eiryss3 attached to the Spears has won me games I probably shouldn't have, Vengeance makes her already great threat ranges kinda nutty.